Understanding 22q11.2 Deletion Syndrome by multi-species Analysis of Neurolethal Genes in Development

22q11.2DS, also known as DiGeorge Syndrome, occurs when a small piece of chromosome 22 is missing in the genes. The disorder is responsible for various neurological disorders affecting learning, behavior, and mental health in children and adolescents. To date, no cure is available for the disorder, and management often focuses on treating symptoms. As such, there is a need to understand better how DiGeorge Syndrome affects human genes. In this project, we study DiGeorge Syndrome using fruit flies and mice to understand how key DiGeorge syndrome genes affect human genetic disorders.